Sublingual administration of the drug means placement of the drug under the tongue and drug reaches directly in to the blood stream through the ventral surface of the tongue and floor of the mouth. The concept of formulating Sublingual tablets of Felodipine (antihypertensive drug) offer suitable and practical approach in serving the desired objective of faster disintegration and dissolution characteristic with increase bioavailability and to know the effects of two synthetic superdisintegrants (kyron and Croscarmellose sodium). In the present work comparison between kyron and Croscarmellose sodium was done by taking different ratio (1:1,1:2,2:1,1:3,3:1). Combination of these two superdisintegrants shows synergistic effect when it compared individually. Solid dispersion of the drug is made by using betacyclodextrine to increase the solubility of the drug. Prepared tablets were subjected to different evaluation parameters such as hardness, thickness, friability, weight variation, drug content uniformity, in vitro disintegration time, wetting time, in vitro dissolution studies and stability studies are carried out by using best formulation.
Loading....